Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/10587
Title: Differential delivery of vincristine to A549 cells using Chitosan capped silver nanoparticles under the pH trigger
Authors: Varadharajan, V.
Ramaswamy, A.
Bose, R.
Arumugam, G.K.S.
Issue Date: 2017
Citation: Journal of Bionanoscience, 2017, Vol.11, 1, pp.66-74
Abstract: This study reports chitosan capped biogenically synthesized silver nanoparticles (Chit@AgNPs) of Diameter=12 nm for efficient delivery of vincristine (VCR) to A549 cells under the pH trigger. About 48% w/w of VCR could be loaded to Chit@AgNP without any conjugation system. The infrared spectroscopy indicated the presence of abundant quantities of the hydroxyl group on the surface of VCR loaded Chit@AgNP and it was confirmed by its negative zeta potential (-11.7 mV). Under in vitro condition, the release of VCR from Chit@AgNP into aqueous solution strictly followed first order kinetics with high preference to acidic pH. Significant cytotoxicity was observed in A549 cells than MDCK cells at p > 0-05 when incubated with VCR loaded Chit@AgNP, promoting high specificity towards cancer cells.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/10587
Appears in Collections:1. Journal Articles

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