Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/11369
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dc.contributor.authorJanardhanan, J.C.-
dc.contributor.authorMishra, R.K.-
dc.contributor.authorDas, G.-
dc.contributor.authorSini, S.-
dc.contributor.authorJayamurthy, P.-
dc.contributor.authorSuresh, C.H.-
dc.contributor.authorPraveen, V.K.-
dc.contributor.authorManoj, N.-
dc.contributor.authorBabu, B.P.-
dc.date.accessioned2020-03-31T08:31:13Z-
dc.date.available2020-03-31T08:31:13Z-
dc.date.issued2018-
dc.identifier.citationAsian Journal of Organic Chemistry, 2018, Vol.7, 10, pp.2094-2104en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/11369-
dc.description.abstractDevelopment of small-molecule-based multi-luminescent fluorophores utilizing simple synthetic methodologies, as well as easily available starting materials, has gained much attention in recent years. Herein, we disclose an efficient protocol for the synthesis of N-protected 1H-indazole derivatives with diverse substituents at their 3- and 5-positions via palladium-catalyzed reactions of hydrazones and p-benzoquinones. The obtained 1H-indazole derivatives can be easily modified into donor-acceptor (D?A)-type chromophores (Indazo-Fluors) with tunable emission properties in both solid and solution state. Owing to the extent of intramolecular charge transfer, Indazo-Fluors exhibit positive solvatochromic emission spanning from blue-green to orange-red. Theoretical studies were undertaken to rationalize the observed trends in the optical properties of Indazo-Fluors. Finally, a triethylene glycol (TEG) appended Indazo-Fluor exhibiting a large Stokes shift and low cytotoxicity allowed us to use it for cell imaging. 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.titleFunctionalizable 1H-Indazoles by Palladium Catalyzed Aza-Nenitzescu Reaction: Pharmacophores to Donor-Acceptor Type Multi-Luminescent Fluorophoresen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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