Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/12216
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dc.contributor.authorPanathur, N.-
dc.contributor.authorGokhale, N.-
dc.contributor.authorUdayakumar, D.-
dc.contributor.authorKoushik, P.V.-
dc.contributor.authorYogeeswari, P.-
dc.contributor.authorSriram, D.-
dc.date.accessioned2020-03-31T08:38:48Z-
dc.date.available2020-03-31T08:38:48Z-
dc.date.issued2015-
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, 2015, Vol.25, 14, pp.2768-2772en_US
dc.identifier.urihttps://idr.nitk.ac.in/jspui/handle/123456789/12216-
dc.description.abstractA new series of indole-isoxazolone hybrids bearing substituted amide, substituted [(1,2,3-triazol-4-yl)methoxy]methyl group or substituted benzylic ether at position-2 of the indole nucleus was synthesised using a facile synthetic route and the molecules were characterised using spectroscopic techniques. The molecules were screened against three human cancer cell lines to evaluate their in vitro cytotoxic property. Most of the trifluoromethyl substituted derivatives exhibited better growth inhibition activity than their methyl substituted analogues. The SIRT1 inhibition activity of two potent molecules (I17 and I18) was investigated and the SIRT1 IC<inf>50</inf> values are 35.25 and 37.36 ?M, respectively for I17 and I18. The molecular docking studies with SIRT1 enzyme revealed favourable interactions of the molecule I17 with the amino acids constituting the receptor enzyme. 2015 Elsevier Ltd. All rights reserved.en_US
dc.titleNew indole-isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studiesen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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