One-step synthesis of biaryls under mild conditions

Abstract

A one-step synthesis of symmetrical biaryls was developed and uses a nickel(III) complex containing a Schiff base and dithiolate ligands as a catalyst for the homocoupling of in situ generated Grignard reagents. The coupling reaction was performed at room temperature with molecular oxygen as the oxidant, which renders the reaction energy-efficient and environmentally friendly. The catalytic methodology is compatible with diverse functionalities, including chlorido, nitro, nitrile, and heteroatoms, and provides biaryls in appreciable yields. A practical, room-temperature nickel(III) catalytic system has been developed for the synthesis of biaryls in one step from the homocoupling of in situ generated Grignard reagents. The use of molecular oxygen as the oxidant makes the system environmentally friendly. The reaction system is compatible with diverse functionalities and affords biaryls in appreciable yields. Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.