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dc.contributor.authorGopkumar, P.
dc.contributor.authorMugeraya, G.
dc.date.accessioned2020-03-31T08:39:22Z-
dc.date.available2020-03-31T08:39:22Z-
dc.date.issued2010
dc.identifier.citationResearch Journal of Pharmaceutical, Biological and Chemical Sciences, 2010, Vol.1, 3, pp.826-831en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/12482-
dc.description.abstractIn the present study, the fungal biotransformation of 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) is presented. Biocatalysis, isolation and subsequent structure elucidation of the newly transformed metabolite (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) is presented. Microbial transformation of Vasicine (I) by Aspergillus niger, Rhizopus arrhizus, Pencillium notatum and Trematus versicolor afforded (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) (100%) as the sole metabolic product. 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) and (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) screened for antibacterial and antifungal activity.en_US
dc.titleMicrobial transformation of bioactive natural productsen_US
dc.typeArticleen_US
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