Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/13278
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dc.contributor.authorVijesh, A.M.-
dc.contributor.authorIsloor, A.M.-
dc.contributor.authorIsloor, S.-
dc.contributor.authorShivananda, K.N.-
dc.contributor.authorShyma, P.C.-
dc.contributor.authorArulmoli, T.-
dc.date.accessioned2020-03-31T08:45:31Z-
dc.date.available2020-03-31T08:45:31Z-
dc.date.issued2011-
dc.identifier.citationDer Pharma Chemica, 2011, Vol.3, 4, pp.454-463en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13278-
dc.description.abstractInvasive microbial infections are major problems around the world, especially in immuno compromised patients. The recent expansion of antimicrobial drug research has occurred because there is a critical need for new antimicrobial agents to treat these life threatening invasive infections. In the present study three series of new substituted pyrazolone derivatives (5a-f, 6a-f and 8a,b) were synthesized by the Knoevenagel condensation reaction of pyrazolones (3a,b) with various substituted carbaldehydes (4a-f, 7). These newly synthesized compounds were characterized by IR, NMR, mass spectra and also by C, H, N analyses. New compounds were screened for their antimicrobial studies against S. aureus, B. subtilis, E. coli and P. aeruginosa. The results revealed that compounds 5c and 6c having 2,5-dichlorothiophene substituent showed significant antibacterial activity against all tested microorganisms as compared to the standard drug Ceftriaxone.en_US
dc.titleSynthesis of some new pyrazolone derivatives as potent antimicrobial agentsen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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