Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/13280
Title: Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents
Authors: Wagle, S.
Adhikari, A.V.
Kumari, N.S.
Issue Date: 2008
Citation: Phosphorus, Sulfur and Silicon and the Related Elements, 2008, Vol.183, 5, pp.1285-1300
Abstract: A series of 4-aryl-2-(3-methyl-7-substituted quinoxaline-2-one-1-yl)-1,3- thiazoles (6a-l) and 4-substituted alkyl-2-(3-methyl-7-substituted quinoxaline-2-one-1-yl)-1,3-thiazoles (8a-i) were synthesized in good yield by condensing 2-(3-methyl-7-substituted l,2-oxoquinoxalin-1(2H)-yl)ethanethioamides (5a-c) with substituted phenacyl bromide and dichloroacetone followed by treatment with secondary amines, respectively. The intermediates, 5a-c were conveniently obtained by reacting phosphorus pentasulphide with 2-(3-methyl-7-substituted-2-oxoquinoxalin-1(2H)-yl) acetamides (4a-c) which in turn were synthesized from ethyl (3-methyl-7-substituted-2-oxoquinoxalin-1(2H)- yl) acetates (3a-c) by aqueous ammonia treatment. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and Mass spectral and elemental analyses. These compounds were screened for in vitro antibacterial activity against five pathogenic strains and antifungal activity against four fungi. Preliminary results revealed that some of the synthesized compounds showed promising antimicrobial activity. Copyright Taylor & Francis Group, LLC.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/13280
Appears in Collections:1. Journal Articles

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