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dc.contributor.authorOruganti, M.
dc.contributor.authorKhade, P.
dc.contributor.authorDas, U.K.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2020-03-31T08:45:44Z-
dc.date.available2020-03-31T08:45:44Z-
dc.date.issued2016
dc.identifier.citationRSC Advances, 2016, Vol.6, 19, pp.15868-15876en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13381-
dc.description.abstractA series of two salts of isoniazid and two cocrystals of its Schiff base have been synthesised and characterized using FT-IR, 1H-NMR, DSC, XRPD and SCXRD. The crystal structures with 2,5-dihydroxybenzoic acid, 2,6-dihydroxy benzoic acid, 3-aminobenzoic acid and o-phthalic acid have been deduced. In all complexes the involvement of pyridine N (proton transfer/robust synthon) is noticed. The unit cell similarity index was calculated between two cocrystals (N-(propan-2-ylidene)isonicotinohydrazide) (2,5-dihydroxybenzoic acid) and (3-aminobenozic acid) (N-(propan-2-ylidene)isonicotinohydrazide). Furthermore, the index was compared with the reported complexes and it was found to be close to zero indicating isostructurality. The correlation between the NPyr-H?O (acid) hydrogen bond distance for the reported cocrystals and their corresponding pKa values has been deduced and validated. The Royal Society of Chemistry 2016.en_US
dc.titleThe hierarchies of hydrogen bonds in salts/cocrystals of isoniazid and its Schiff base - A case studyen_US
dc.typeArticleen_US
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