Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/9532
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dc.contributor.authorSunil, D.-
dc.contributor.authorIsloor, A.M.-
dc.contributor.authorShetty, P.-
dc.contributor.authorSatyamoorthy, K.-
dc.contributor.authorBharath, Prasad, A.S.-
dc.date.accessioned2020-03-31T06:51:08Z-
dc.date.available2020-03-31T06:51:08Z-
dc.date.issued2010-
dc.identifier.citationArabian Journal of Chemistry, 2010, Vol.3, 4, pp.211-217en_US
dc.identifier.uri10.1016/j.arabjc.2010.06.002-
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/9532-
dc.description.abstractIn this paper we have investigated the in vitro antioxidant property of two triazolo-thiadiazoles, 6-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (FPNT) and 6-[3-(4-chlororophenyl)-1H-pyrazol-4-yl]-3-[(phenyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (CPPT) by spectrophotometric DPPH and ABTS radical scavenging methods as well as by lipid peroxide assay. The anticancer activity along with possible mechanism of action of triazolo-thiadiazoles in Hep G2 cells was explored using MTT assay, [3H] thymidine assay, flow cytometry and chromatin condensation studies. Both FPNT and CPPT exhibited a dose dependent cytotoxic effect on hepatocellular carcinoma cell line, HepG2. The IC50 value was very low for both the compounds when compared to standard drug, doxorubicin. Incorporation of [3H] thymidine in conjunction with cell cycle analysis suggested that FPNT inhibited the growth of HepG2 cells. Flow cytometric studies revealed more percentage of cells in sub-G1 phase, indicating apoptosis, which was further confirmed through chromatin condensation studies by Hoechst staining. FPNT was found to be a potent antioxidant when compared to the standard in DPPH, ABTS radical scavenging assays and lipid peroxidation studies. 2010 .en_US
dc.title6-[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole as a potent antioxidant and an anticancer agent induces growth inhibition followed by apoptosis in HepG2 cellsen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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