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Title: | A highly efficient and green cascade synthesis of 3-methyl-substituted-4- hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions |
Authors: | Bhat, S.I. Trivedi, D.R. |
Issue Date: | 2014 |
Citation: | RSC Advances, 2014, Vol.4, 22, pp.11300-11304 |
Abstract: | An expeditious and green protocol for the synthesis of 3,3?- methanediylbis(4-hydroxy-1-methylquinolin-2(1H)-one) (MDBHQ) derivatives and 3-((2-amino-6-oxocyclohex-1-enyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one (AOCHQ) derivatives has been developed via a cascade Knoevenagel-Michael reaction. The products were obtained in high yield under neat reaction conditions without any work-up or chromatographic purification. The generality and functional tolerance of this environmentally benign protocol is demonstrated. 2014 The Royal Society of Chemistry. |
URI: | 10.1039/c3ra45208e http://idr.nitk.ac.in/jspui/handle/123456789/9610 |
Appears in Collections: | 1. Journal Articles |
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