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Title: | An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition |
Authors: | Bhat, S.I. Das, U.K. Trivedi, D.R. |
Issue Date: | 2015 |
Citation: | Journal of Heterocyclic Chemistry, 2015, Vol.52, 4, pp.1253-1259 |
Abstract: | An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. 2014 HeteroCorporation. |
URI: | 10.1002/jhet.2220 http://idr.nitk.ac.in/jspui/handle/123456789/9878 |
Appears in Collections: | 1. Journal Articles |
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