Please use this identifier to cite or link to this item: https://idr.l1.nitk.ac.in/jspui/handle/123456789/13292
Title: Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles
Authors: Vijesh, A.M.
Isloor, A.M.
Prabhu, V.
Ahmad, S.
Malladi, S.
Issue Date: 2010
Citation: European Journal of Medicinal Chemistry, 2010, Vol.45, 11, pp.5460-5464
Abstract: In the present study a series of novel 2,4-disubstituted thiazole derivatives containing substituted pyrazole moiety was synthesized by the reaction of 3-Aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazone with 6-Bromo/H-3-(bromoacetyl)-2H-chromen-2-one/phenacyl chloride. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for their antibacterial studies against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The results revealed that compounds 7c, 8e, and 8f having 2,5-dichlorothiophene substituent and 8c, 8d having 2,4-dichlorophenyl substituent showed significant antibacterial activity against all tested microorganisms. 2010 Elsevier Masson SAS. All rights reserved.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/13292
Appears in Collections:1. Journal Articles

Files in This Item:
File Description SizeFormat 
13292.pdf147.69 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.